Physical Symptoms:

1. Abnormal appetite:
   • Most depressed patients experience loss of appetite and weight loss. The opposite, excessive eating and weight gain, occurs in a minority of depressed patients. Changes in weight can be significant.
2. Abnormal sleep:
   • Most depressed patients experience difficulty falling asleep, frequent awakenings during the night or very early morning awakening. The opposite, excessive sleeping, occurs in a minority of depressed patients.
3. Fatigue or loss of energy:
   • Profound fatigue and lack of energy usually is very prominent and disabling.
4. Agitation or slowing:
   • Psychomotor retardation (an actual physical slowing of speech, movement and thinking) or psychomotor agitation (observable pacing and physical restlessness) often are present in severe Major Depressive Disorder.
    

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